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Inhibitors?Agonists?Screening Librarieswww.MedChemExpress.cn15-Deoxy-Δ-12,14-prostaglandin J2Cat. No.:CAS No.:Synonyms:HY-10856887893-55-815d-PGJ2; 15-Deoxy-Δ12,14-PGJ2C??H??O?316.43PPAR; Endogenous MetaboliteCell Cycle/DNA Damage; Metabolic Enzyme/ProteasePlease store the product under the recommended conditions in the COA.分?式:分?量:作?靶点:作?通路:储存?式:BIOLOGICAL ACTIVITY?物活性15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) 是?种环戊烯酮前列腺素和 PGD2 的代谢产物。15-Deoxy-Δ-12,14-prostaglandin J2 是?种选择性的 PPARγ (EC50 为 2 μM) 和共价的 PPARδ 激动剂。15-Deoxy-Δ-12,14-prostaglandin J2 促进 C3H10T1/2 成纤维细胞向脂肪细胞的有效分化，EC50 为 7 μM。IC50 & TargetPPARγ2 μM (EC50)PPARδ Human Endogenous Metabolite 体外研究15-Deoxy-Δ12,14-PGJ2 (15d-PGJ2) is a cyclopentenone prostaglandin that features an electrophilic, α, β-unsaturated ketone (an enone) in the cyclopentenone ring. 15-Deoxy-Δ-12,14-prostaglandin J2 is one of the cyPGs whose functions in inflammation, cell proliferation, survival, and apoptosis have been documented. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ in a dose-dependent manner. 15-Deoxy-Δ-12,14-prostaglandin J2 activates PPARδ’s transcriptional activity through formation of a covalent adduct between its endocyclic enone at C9 and Cys249 in the receptor’s ligand-binding domain [1]. REFERENCES[1]. Reddy AT, et al. Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2. CS Chem Biol. 2018 Dec 21;13(12):3269-3278.[2]. Kliewer SA1, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9.McePdfHeight1/1Master of Small Molecules —您?边的抑制剂?师
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15-Deoxy-12-14-prostaglandin-J2-15d-PGJ2-DataSheet-MedChemExpress
