组织因子途径抑制物及前降钙素在新生儿败血症诊断中的
价值
孙先军;李晶;邓冬梅;焦国立;刘利梅;郑平
【期刊名称】《中国小儿急救医学》 【年(卷),期】2009(016)002
【摘要】Objective Neonatal septicemia is a critical disease in neonatal period.The early signs of septicemia in the newbom are generally nonspecific.Blood culture and the other clinical diagnostic measures are not sufficiently sensitive.The present study aimed at evaluating potential use of tissue factor pathway inhibitor(TFPI),procalcitonin(PCT)and C-reactive protein (CRP) in diagnosis of neonatal sepdcemia.Methods Fourty-eight newborn infants with sepdcemia enrolled the study.Twenty of the 48 cases had positive blood culture.The control group included 30 healthy newborns.Fasting blood samples were taken for bacterial cultures
and
TFPI
、
CRP
、
PCT
determination.The
sensitivity,specificity,positive and negative predictive values,Youden's index for TFPI,PCT and CRP were calculated.These values were compared with each other.Results (1) There were significant differences among the three groups in the contents of TFPI,CRP and PCT(P＜0.05).These markers were considered were considered positive if TFPI≥30μg/L、CRP≥8 mg/L,PCT≥2 ng/ml.Among these indices,PCT had the
highest
specificity(96.67%),positive
predictive
value
组织因子途径抑制物及前降钙素在新生儿败血症诊断中的价值
