口服布洛芬治疗早产儿动脉导管未闭疗效和安全性的meta分析

口服布洛芬治疗早产儿动脉导管未闭疗效和安全性的meta

分析

张鹏;孟靓靓;程国强

【期刊名称】《中华围产医学杂志》 【年(卷),期】2013(016)005

【摘要】Objective To evaluate the efficacy and safety of oral ibuprofen for

closure

of patent

ductus

arteriosus

(PDA)

in

preterm

infants.Methods The related literatures till December 31st,2011 in Cochrane

Library,PubMed,EMBASE,Ovid,Springer,China

Academic

Journal Full-text Database,Wanfang Database,VIP Database and China Biological Medical Literature Database were searched.The inclusion criteria were:(1) the subject of the research was preterm infants with birth weight less than 2500 g and/or gestational age less than 37 weeks; (2) randomized or semirandomized controlled trial; (3) the intervention group received oral ibuprofen,while the control group received oral placebos / intravenous indomethacin or ibuprofen; (4) the main outcome was the failure rate of PDA closure; (5) hemodynamic changes with PDA were detected by ultrasonography.Meta-analysis was performed by Review Manager 4.22 software.Results Eleven randomized controlled trials were included,among which,three were high quality reports.Meta-analysis showed lower failure rate of PDA closure in subjects received oral ibuprofen than in those received placebos orally