Product Data?SheetImiquimodCat. No.:CAS No.:分?式:分?量:作?靶点:作?通路:储存?式:HY-B018099011-02-6C??H??N?240.3Toll-like Receptor (TLR); Autophagy; HSVImmunology/Inflammation; Autophagy; Anti-infectionPowderIn solvent-20°C4°C-80°C-20°C3 years2 years6 months1 monthInhibitors?Agonists?Screening Libraries溶解性数据体外实验DMSO : 1.43 mg/mL (5.95 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)Mass1 mg5 mg10 mgSolventConcentration制备储备液1 mM5 mM10 mM4.1615 mL0.8323 mL---20.8073 mL4.1615 mL---41.6146 mL8.3229 mL---请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；?旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存?式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个?内使?，-20°C 储存时，请在 1 个?内使?。BIOLOGICAL ACTIVITY?物活性IC?? & Target体内研究Imiquimod (R 837) 是?种免疫反应调节剂，作为 toll-like receptor 7 的激动剂起作?。toll-like receptor 7[1]In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secretecytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].Page 1 of 2 www.MedChemExpress.cn
客户使?本产品发表的科研?献
????Nat Commun. 2016 May 25;7:11724.????Biomaterials. 2019 Jan.
See more customer validations on www.MedChemExpress.cnREFERENCES
[1].?Bilu D, et al. Imiquimod: modes of action. Br J Dermatol. 2003 Nov;149 Suppl 66:5-8.
McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.
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