Calix[4]arene-Based Enantioselective Fluorescent Sensors for the Recognition of N-Acetyl-aspartate

Calix[4]arene-Based Enantioselective Fluorescent Sensors for the Recognition of N-Acetyl-aspartate

QING Guang-Yan;CHEN Zhi-Hong;WANG Feng;YANG Xi;MENG Ling-Zhi;HE Yong-Bing

【期刊名称】《中国化学（英文版）》 【年(卷),期】2008(026)004

【摘要】Two-armed chiral anion receptors (1 and 2), calix[4]arenes bearing

dansyl

fluorophore

and

(1R,2R)-

or(1S,2S)-1,2-

diphenylethylenediamine binding sites, were prepared and examined for their chiral amino acid anion binding abilities by the fluorescence spectra in dimethylsulfoxide (DMSO). The results of non-linear curve fitting indicate that 1 or 2 forms a 1 : 1 stoichiometry complex with N-acetyl-L-or D-aspartate by multiple hydrogen bonding interactions, exhibiting good enantioselective fluorescent recognition for the enantiomers of N-acetyl-as-partate, [receptor 1: Kass(D)/Kass(L)=6.74; receptor 2: Kass(L)/Kass(D)=6.48]. The clear fluorescent response difference indicates that receptors 1 and 2 could be used as a fluorescent chemosensor for N-Acetyl-aspartate. 【总页数】8页(721-728) 【

关

键

词

】

enantioselective

recognition;calixarene;N-acetyl-

aspartate;fluorescent sensor

【作者】QING Guang-Yan;CHEN Zhi-Hong;WANG Feng;YANG Xi;MENG Ling-Zhi;HE Yong-Bing