The Gut Microbiota, Tumorigenesis, and Liver
Diseases
Guishuai Lv;Ningtao Cheng;Hongyang Wang
【期刊名称】《工程（英文）》 【年(卷),期】2017(003)001
【摘要】In recent decades, diseases concerning the gut microbiota have presented some of the most serious public health problems worldwide. The human host's physiological status is influenced by the intesti-nal microbiome, thus integrating external factors, such as diet, with genetic and immune signals. The notion that chronic inflammation drives carcinogenesis has been widely established for various tissues. It is surprising that the role of the microbiota in tumorigenesis has only recently been recognized, giv-en that the presence of bacteria at tumor sites was first described more than a century ago. Extensive epidemiological studies have revealed that there is a strong link between the gut microbiota and some common cancers. However, the exact molecular mechanisms linking the gut microbiota and cancer are not yet fully understood.Changes to the gut microbiota are instrumental in determining the occurrence and progression of hepatocarcinoma, chronic liver diseases related to alcohol, nonalcoholic fatty liver disease (NAFLD), and cirrhosis. To be specific, the gut milieu may play an important role in systemic inflammation, endotoxemia, and vasodilation,
The Gut Microbiota, Tumorigenesis, and Liver Diseases
