重复经颅磁刺激对血管性认知功能障碍大鼠学习记忆的干
预作用
盛倩倩;闫丽丽;陶华英
【期刊名称】《中华老年心脑血管病杂志》 【年(卷),期】2013(015)003
【摘要】Objective To study the effect of repetitive transcranial magnetic stimulation(rTMS) on learning,memory and hippocampal CAl area EEG frequencies of rats with vascular cognitive im pairment (VCD. Methods Forty healthy male SD rats were randomly divided into control group (n = 8),VCI group(n = 10) ,low frequency(LF) group(n=ll) and high and low frequency(HLF) group(?=ll). A VCI rat model was established by ligating the bilateral common carotid arteries. EEG frequencies in hippocampal CAl region were recorded during the Morris water maze test with a stereotaxic device before and after the VCI model was established. Results Morris water maze test showed that the EEG frequencies in hippocampal CAl region were significantly higher in LF and HLF groups and significantly lower in VCI group after 5 courses of rTMS(P<0. 05). EEG frequencies analysis displayed that the 8 and 6 power was significantly lower whereas the a and β power was significantly hugher in VCI group than in LF group and HLF group after rTMS(P< 0. 05). The a and β power was significantly lower while the δ and θ power was significantly higher in VCI group after the VCI model was
重复经颅磁刺激对血管性认知功能障碍大鼠学习记忆的干预作用
