Induction of fibroblasts to neurons through
adenoviral gene delivery
Fengxi
Meng;Siye
Chen;Qinglong
Miao;Kechun
Lao;Xiaohui
Zhou;Qicheng
Zhang;Wenyi Guo;Jianwei Jiao
【期刊名称】《细胞研究（英文版）》 【年(卷),期】2012(022)002
【摘要】Dear Editor,The direct conversion of mouse fibroblasts to neurons [1] was developed while many scientists were interested in neuronal differentiation using induced pluripotent stem cells (iPSCs) [2].This direct reprogramming skips a pluripotent state,making patient- and/or disease-specific cell therapy much faster and more feasible.Recent reports have indicated that mouse or human fibroblasts could be directly converted to a number of different cell types,such as cardiomyocytes,blood
progenitor
cells,hepatocyte-like
cells,neural
progenitors and specific dopaminergic neurons [3-9].However,all of the studies in this field have employed the retroviral or lentiviral vector delivery system.
【总页数】5页(436-440) 【关键词】
【作者】Fengxi Meng;Siye Chen;Qinglong Miao;Kechun Zhou;Qicheng Lao;Xiaohui Zhang;Wenyi Guo;Jianwei Jiao
【作者单位】Department of ophthalmology, Eye & ENT Hospital, Fudan
Induction of fibroblasts to neurons through adenoviral gene delivery
