Intensified Antiplatelet Treatment Reduces Major Cardiac Events in Patients with Clopidogr

Intensified Antiplatelet Treatment Reduces Major Cardiac Events in Patients with Clopidogrel Low Response: A Meta-analysis of Randomized

Controlled Trials

Lei Xu;Xiao-Wei Hu;Shu-Hua Zhang;Ji-Min Li;Hui Zhu;Ke Xu;Jun Chen

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2016(129)008

【摘要】Background:Clopidogrel low response (CLR) is an independent risk factor of adverse outcomes in patients undergoing percutaneous coronary intervention (PCI),and intensified antiplatelet treatments (IAT) guided by platelet function assays might overcome laboratory CLR.However,whether

IAT

improves

clinical

outcomes

is

controversial.Methods:Relevant trials were identified in PubMed,the Cochrane Library,and the Chinese Medical Journal Network databases from their establishment to September 9,2014.Trials were screened using predefined inclusion criteria.Conventional meta-analysis and cumulative meta-analysis were performed using the Review Manager 5.0 and STATA 12.0 software programs.Results:Thirteen randomized controlled trials involving 5111 patients with CLR were recruited.During a follow-up period of 1-12 months,the incidences of cardiovascular (CV) death,nonfatal myocardial infarction (MI),and stent thrombosis were significantly lower in the IAT arm than in the conventional antiplatelet

treatment arm (relative risk [RR] =0.45,95％ confidence interval [CI]:0.36-0.57,P ＜ 0.000,01),whereas bleeding was similar between the two arms (RR =1.05,95％ CI:0.86-1.27,P =0.65).Conclusions:IAT guided by platelet function assays reduces the risk of CV death,nonfatal MI,and stent thrombosis (ST) without an increased risk of bleeding in patients undergoing PCI and with CLR. 【总页数】8页(984-991) 【关键词】

【作者】Lei Xu;Xiao-Wei Hu;Shu-Hua Zhang;Ji-Min Li;Hui Zhu;Ke Xu;Jun Chen

【作者单位】Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China;Department of Cardiology, Sir Yifu Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 211166, China;Coronary Artery Disease Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China;Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China;Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China;Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China;Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China;Department

of Cardiology, People's Hospital of Maanshan City, Maanshan, Anhui 243000, China 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-medical-journal_thesis/0201254254705.html 【相关文献】

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