Chronic blocking of β3-adrenoceptor ameliorates cardiac function in rat model of heart fa

Chronic blocking of β3-adrenoceptor ameliorates cardiac function in rat model of heart failure

function in rat model of heart failure

GAN Run-tao;LI Wei-min;XIU Chun-hong;SHEN Jing-xia;WANG Xu;WU Shuang;KONG Yi-hui

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2007(120)024

【摘要】Background Stimulation of the heart β3-adrenoceptor(AR)may result in a negative inotropic effect.Being up-regulated,β3-AR plays a more important role in the regulation of cardiac function during heart failure.However,the effect of chronic blocking of β3-AR on heart failure has not been fully elucidated.In this study,we used a selective β3-AR antagonist SR59230A to treat a well defined heart failure rat model chronically,then evaluated its effect on cardiac function and investigated the mechanism.Methods Male Wistar rats were chosen randomly as controls (n=8).Isoproterenol induced heart failure rats were randomly divided into ISO group(n=10) and SR group(n=10).The ISO group received intraperitoneal injection of 1 ml saline twice a day;the SR group received intraperitoneal injection of SR59230A 85 nmol in 1 ml saline twice a day;and the controI group received no treatment.The treatment was started 24 hours after the last isoproterenol injection and continued for 7 weeks.Then we measured the following indexes:the