YKL-40在动脉粥样硬化中的作用
吴雪松;储照虎;徐阳;赵学廉
【期刊名称】《国际脑血管病杂志》 【年(卷),期】2011(019)008
【摘要】YKL-40 (human cartilage glycoprotein 39) is a newly discovered inflammatory cytokine, which belongs to the member of 18 glycosyl hydrolase of mammal family. Previous studies have indicated that YKL-40 is associated with the acute or chronic inflammatory diseases and tumors. Studies in recent years have suggested that YKL-40 may be involved in the occurrence and development of atherosclerotic plaques, and it is correlated with the plaque instability. The physiological function and the mechanisms of YKL-40 are not fully understood. It may have the roes of promoting vascular smooth muscle migration and proliferation, promoting cell adhesion and proliferation, as well as regulating extracellular matrix remodeling The detection of YKL-40 may have some significance in the aided diagnosis, predicting prognosis, prevention
of
cardiocerebrovascular
diseases,
and
even
the
establishment of new therapeutic strategies.%YKL-40（人软骨糖蛋白-39）是一种新发现的炎性因子，属于哺乳动物18-糖基水解酶家族成员。既往研究表明，YKL-40与急慢性炎症性疾病和肿瘤等有关。近年来的研究显示，YKL-40可能参与了动脉粥样硬化斑块的发生和发展，并且与斑块不稳定性相关。YKL-40的生物学功能和作用机制尚不完全清楚，可能具有促进血管平滑肌迁移
YKL-40在动脉粥样硬化中的作用
