Baseline Naive CD4+ T-cell Level Predicting Immune Reconstitution in Treated HIV-infected

Baseline Naive CD4+ T-cell Level Predicting Immune Reconstitution in Treated HIV-infected

Late Presenters

Fu-Ping Guo;Yi-Jia Li;Zhi-Feng Qiu;Wei Lv;Yang Han;Jing Xie;Yan-Ling Li

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2016(129)022

【摘要】Background:Among HlV-infected patients initiating antiretroviral therapy (ART),early changes in CD4+ T-cell subsets are well described.However,HIV-infected late presenters initiating treatment present with a suboptimal CD4+ T-cell reconstitution and remain at a higher risk for AIDS and non-AIDS events.Therefore,factors associated with CD4+ T-cell reconstitution need to be determined in this population,which will allow designing effective immunotherapeutic strategies.Methods:Thirty-one adult patients with baseline CD4+ T-cell count ＜350 cells/mm3 exhibiting viral suppression after ART initiation were followed in the HIV/AIDS research center of Peking Union Medical College Hospital in Beijing,China,from October 2002 to September 2013.Changes in T-cell subsets and associated determinants were measured.Results:Median baseline CD4+ T-cell count was 70 cells/mm3.We found a biphasic reconstitution ofT-cell subsets and immune activation:a rapid change during the first 6 months followed by a more gradual change over the subsequent 8 years.Baseline CD4+ T-