复发转移性三阴性乳腺癌临床特征及总生存分析
赵丹;邸立军;冉然;王环;张嘉扬;宋国红;李惠平;邵彬;张如艳;严颖;孔维垚;刘笑然;刘雅昕
【期刊名称】《癌症进展》 【年(卷),期】2016(014)012
【摘要】Objective To analyze the management, recurrence rate, and overall survival of patients with triple nega-tive breast cancer (TNBC). Method Retrospective analysis was performed for 78 patients who developed advanced dis-ease, of which the clinical characteristics, recurrence, treatment, and survival were evaluated. Result For the 78 pa-tients, the overall survival (OS) was 6-236 months (median OS:32.1 months). The 1-, 5-and 10-year survival rate was 92.3%, 28.2%, and 6.4%, respectively. 71 (91%) patients who received radical surgery or modified radical mastectomy showed a disease-free survival (DFS) of 1-184 months, and median DFS was 15.0 months, 7 (9.0%) patients were in stage IV initially. The TNBC patients at stage I had OS of 19.7-236 months (median OS:90.0 months). While the OS was 3.0-93.3 months (median OS:14.4 months) after recurrence and metastasis. 13 (16.7%) patients with local recur-rence or limited distant metastasis who received local surgery plus systemic therapy had 26.5 months of median OS, whereas 65 (83.3%) cases who just received systemic therapy achieved only 12.2 months of median OS (P=0.034). For patients treated with or without taxane-based first-line therapy, the median OS was 14.6
复发转移性三阴性乳腺癌临床特征及总生存分析
