小剂量 rt－PA 静脉溶栓治疗急性脑梗死的临床观察
赵惠荣;元小冬;郭晶;王燕玲
【期刊名称】《河北联合大学学报（医学版）》 【年(卷),期】2015(000)001
【摘要】①目的探讨小剂量重组组织型纤溶酶原激活剂（rt－PA）治疗急性脑梗死的疗效及安全性。②方法发病6h内的急性脑梗死患者30例，分为溶栓组（16例，接受rt－PA 40mg静脉溶栓治疗）和对照组（14例，未使用rt－PA，其他治疗同溶栓组）。记录治疗前与治疗后2、24h、10d的NIHSS评分及10d时的Barthel指数，并复查头颅CT，进行疗效和安全性评价。③结果两组治疗后 NIHSS评分较治疗前均有改善，溶栓组较对照组改善更明显，两组比较差异有统计学意义（ P ＜0．05）。溶栓组治疗的总有效率高于对照组（75％、50％， P ＜0．05），溶栓组出现牙龈出血1例，两组均无颅内出血及死亡病例。④结论在严格控制适应证的前提下，小剂量rt－PA治疗急性脑梗死安全有效，优于常规治疗。%[ ABSTRACT] Objective To evaluate the efficacy and safety of low dose rt-PA in the early treatment of the patients with acute cerebral infarction.Methods 30 patients within 6 hours from the onset of stroke were divided into 2 groups, thrombolytic group(16 cases)and control group(14cases).Patients in thrombolytic group received rt-PA 40mg, patients in control group did not receive thrombolytic therapy.NIHSS and Barthel Index ( BI) were used to evaluate the recovery of neurological functions after rt-PA 2 , 24 hours and 10 days.Cerebral CT were also reexamined.Results The scores of
小剂量 rt-PA 静脉溶栓治疗急性脑梗死的临床观察
