Traditional Chinese medicine molecule-assisted chemical synthesis of fluorescent anti-canc

Traditional Chinese medicine molecule-assisted chemical synthesis of fluorescent anti-cancer

silicon nanoparticles

Xiaoyuan Ji;Daoxia Guo;Bin Song;Sicong Wu;Binbin Chu;Yuanyuan Su;Yao He

【期刊名称】《纳米研究（英文版）》 【年(卷),期】2018(011)010

【摘要】Fluorescent silicon (Si) nanoparticles (SiNPs) hold great promise for innumerable biological and biomedical applications owing to their unique optical properties and negligible toxicity.In this article,we present a new traditional Chinese medicine (TCM) molecule-assisted chemical

synthetic

strategy,suitable

for

the

production

of

multifunctional small-sized (diameter:～ 3.7 nm) SiNPs in a facile and rapid (～ 10 min) manner.Of particular significance,the resultant SiNPs simultaneously

exhibited

robust

and

stable

fluorescence

(photoluminescence quantum yield (PLQY):～ 15％),as well as intrinsic anti-cancer efficacy with excellent selectivity toward cancer cells.Taking advantage of these unique merits,we further employed these novel fluorescent anti-cancer SiNPs (AC-SiNPs) for the fluorescence tracking and treatment of tumors,demonstrating long-term (～ 18 days) inhibition of tumor growth in tumor-bearing mice.Consequently,we believe this new TCM-assisted chemical synthetic method is highly attractive for designing silicon nanostructures featuring multiple

functionalities,and we suggest these AC-SiNPs as novel promising tools for providing visual evidence of TCM-based cancer treatment. 【总页数】13页(5629-5641) 【关键词】

【作者】Xiaoyuan Ji;Daoxia Guo;Bin Song;Sicong Wu;Binbin Chu;Yuanyuan Su;Yao He

【作者单位】Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials(FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China;Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials(FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China;Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials(FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China;Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials(FUNSOM), Collaborative

Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China;Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials(FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China;Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials(FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China;Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials(FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China 【正文语种】英文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_nano-research-english_thesis/0201271732768.html 【相关文献】

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