Role of inflammatory cytokines in peripheral nerve
injury
Federica Fregnan;Luisa Muratori;Anabel Rodriguez Sim(o)es;Maria Giuseppina Giacobini-Robecchi;Stefania Raimondo
【期刊名称】《中国神经再生研究（英文版）》 【年(卷),期】2012(007)029
【摘要】Inflammatory events occurring in the distal part of an injured peripheral nerve have,nowadays,a great resonance.Investigating the timing of action of the several cytokines in the important stages of Wallerian degeneration helps to understand the regenerative process and design pharmacologic intervention that promotes and expedites recovery.The complex and synergistic action of inflammatory cytokines finally promotes axonal regeneration.Cytokines can be divided into pro-and
anti-inflammatory
cytokines
that
upregutate of
and
downregulate,respectively,the production inflammatory
mediators.While pro-inflammatory cytokines are expressed in the first phase of Wallerian degeneration and promote the recruitment of macrophages,anti-inflammatory cytokines are expressed after this recruitment and downregulate the production of all cytokines,thus determining the end of the process.In this review,we describe the major inflammatory cytokines involved in Wallerian degeneration and the early phases of nerve regeneration.In particular,we focus on interleukin-
Role of inflammatory cytokines in peripheral nerve injury
