Reference intervals for common thyroid function tests, during different stages of pregnanc

Reference intervals for common thyroid function tests, during different stages of pregnancy in

Chinese women

FAN Jian-xia;HAN Mi;TAO Jun;LUO Jun;SONG Meng-fan;YANG Shuai;KHOR Shu-zin

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2013(126)014

【摘要】Background The importance of diagnosis of thyroid dysfunction during pregnancy has been widely recognized.Our study was designed to compare two different detection reagents between Abbott and Roche and to establish the gestational-related reference intervals for thyroid function tests (TFT) in Chinese women and to assay the reference ranges with the American Thyroid Association recommended standard.Methods Serum samples were collected from 693 normal pregnant Chinese women and divided into five groups according to their gestational age:9-13,16-20,24-28,32-34 and 37-40 weeks.Thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were determined by two different detection reagents:Abbott Architect l 2000 and Roche Cobas Elecsys 600.The reference ranges of the TFT indexes were calculated according to the National Academy of Clinical Biochemistry (NACB).The 2.5th and 97.5th percentiles of each stage were calculated,and the results were analyzed by one-way analysis of variances,t-test,and Spearman correlation analysis.Results Thyroid