银杏达莫注射液对肾病综合征患者纤维蛋白原、D-二聚体、
凝血酶激活的纤溶酶抑制物的影响
胡石炜;张道友;杨利才;高潮清;徐海红
【期刊名称】《医学综述》 【年(卷),期】2012(018)018
【摘要】Objective To observe the effect of Ginkgo biloba injection onfibrinogen(
FiB
),D-dimer,
thrombin-activated
fibrinolysis
inhibitor{ TAF1 }of patients with nephrotic syndrome( NS ). Methods 40 cases of primary nephrotic syndrome on admission, were randomly divided into two groups, observation group and control group, each group 20 cases. The control group were treated with conventional treatment: predni-sone lmg/( kg · d )and diuretic swelling, blood lipid-therapy, and oral dipyridamole therapy, while the observation group were given conventional treatment plus Ginkgo biloba intravenous injection :5% glucose 250 mL + 25 mL Ginkgo biloba intravenous injection, 1 time/d for 10 days. Concentration values of relevant indicators were measured at the time of admission and full course of the treatment, respectively. Results There were no significant difference of FiB,D-dimer,TAF1 before and after treatment in the control group,while in the observation group Fib,TAFl were significantly ameliorated( P<0.05 )but D-dimer. After treatment,FiB and TAF1 in the observation group were ameliorated markedly than that in the control
group, but D-dimer ( P>0.05 ). Conclusion Ginkgo biloba injection can ameliorate FiB and TAF1 in NS patients, which can be used to improve hypercoagulability of NS in clinic.%目的观察银杏达莫注射液对肾病综合征(NS)患者纤维蛋白原(FiB)、D-二聚体、凝血酶激活的纤溶酶抑制物的影响.方法 选择40例入院时诊断为原发性NS的患者,观察组和对照组各20例,对照组采用常规治疗:泼尼松1 mg/(kg·d)及利尿消肿、调血脂治疗,并口服双嘧达莫.观察组在常规治疗基础上加用银杏达莫注射液治疗:5%葡萄糖250 mL+银杏达莫注射液25 mL静脉滴注,每日1次,疗程为10 d.分别于入院时及疗程满10 d时检测相关指标的浓度值.结果 对照组FiB、D-二聚体、凝血酶激活的纤溶酶抑制物等治疗后变化无明显差异.观察组FiB、凝血酶激活的纤溶酶抑制物经治疗后有明显改善(P＜0.05),D-二聚体无明显差异.两组治疗后比较,观察组FiB、凝血酶激活的纤溶酶抑制物较对照组有明显改善,但D-二聚体变化无统计学意义(P＞0.05).结论 银杏达莫注射液对于纠正NS患者FiB、凝血酶激活的纤溶酶抑制物有一定疗效,可用于临床改善NS高凝状态. 【总页数】3页(3085-3087)
【关键词】银杏达莫注射液;肾病综合征;纤维蛋白原;D-二聚体;凝血酶激活的纤溶酶抑制物
【作者】胡石炜;张道友;杨利才;高潮清;徐海红
【作者单位】皖南医学院弋矶山医院肾脏内科,安徽,芜湖,241000;皖南医学院弋矶山医院肾脏内科,安徽,芜湖,241000;皖南医学院弋矶山医院肾脏内科,安徽,芜湖,241000;皖南医学院弋矶山医院肾脏内科,安徽,芜湖,241000;皖南医学院弋矶山医院肾脏内科,安徽,芜湖,241000
【正文语种】中文
【中图分类】R331;R453.9 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_medical-recapitulate_thesis/0201252975641.html 【相关文献】
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银杏达莫注射液对肾病综合征患者纤维蛋白原、D-二聚体、凝血酶激
