肾移植术后并发恶性肿瘤的临床研究
田野;张玉海;解泽林;马麟麟;唐雅望;孙雯;郭宏波
【期刊名称】《中华器官移植杂志》 【年(卷),期】1998(019)003
【摘要】1985～1996年共行同种异体肾移植术1 211例,均采用环孢素A、硫唑嘌呤及泼尼松三联免疫抑制治疗.术后发生恶性肿瘤15例,发生率为1.2%.肿瘤发生的部位包括:皮肤、口腔、食道、胃、肺、肝以及泌尿系统,其中泌尿系统恶性肿瘤占9例.移植术后至肿瘤诊断的时间平均为29.2个月.治疗措施为减少环孢素A的用量及肿瘤切除.8例患者发生肿瘤转移,并在1年内死于肿瘤晚期.认为肾移植术后恶性肿瘤的发生及种类因种族和地域的差异而有所不同,在治疗上困难较大,可减少环孢素A的用量至原用量的1/4,如病情不能控制,应以抢救生命为主.%From 1985 to 1996, 1 211 cadaveric kidney transplantation were performed in our hospital. All recipients were treated by CsA+Aza+Pred triple immunosuppressive therapy. Fifteen cases of malignancy (9 males and 6 females) were detected with the overall incidence being 1.2%. The involved organs or tissues included skin, mouth, esophagus, stomach, lung, liver,and urological system (9 patients). The average appearance time of the tumors in the 15 recipients after transplantation was 29.2 (3/84) months. Eight patients with metastasis died within one year of diagnosis. The etiology, clinical features
and
treatment
of
the
malignancy
following
renal
transplantation were discussed. The development and kinds of
肾移植术后并发恶性肿瘤的临床研究
