Effect of Acupuncture at Acupoint Neiguan (PC 6) on the Myocardial c-fos Gene Expression o

Effect of Acupuncture at Acupoint Neiguan (PC 6) on the Myocardial c-fos Gene Expression of Acute

Myocardial Ischemia in Rats

谢芳;梁勋厂;吴红金;茹立强;朱忠春

【期刊名称】《针灸推拿医学（英文版）》 【年(卷),期】2006(004)003

【摘要】目的:探讨电针\内关\改善急性心肌缺血的机制.方法:将96只大鼠随机分为假手术组、心肌缺血模型组、心肌缺血模型加电针组,采用结扎冠状动脉左前降支建立急性心肌缺血实验模型,造模成功后,电针双侧\内关\用生化方法检测血清心肌酶活性,逆转录聚合酶链反应(RT-PCR)方法检测心肌中c-fos基因的表达.结果:心肌缺血模型组血清心肌酶活性和心肌c-fos mRNA表达显著高于假手术组(P＜0.05),电针后降低,差异有显著性意义(P＜0.05).结论:电针\内关\改善急性心肌缺血的机制与下调心肌组织c-fos mRNA的表达有关.%Objective: To investigate the mechanism of improvement effect of electro-acupuncture at acupoint Neiguan (PC 6) on acute myocardial ischemia (AMI). Methods: Ninety-six rats were randomly divided into sham-operation group, myocardial ischemia model group and myocardial ischemia model plus electro-acupuncture group, the rat model of AMI was established by occlusion of the anterior descending branch of the left coronary artery, then electro-acupuncture therapy was performed at bilateral acupoint Neiguan (PC 6). The myocardial enzyme activities in plasma was detected with biochemical method, and the myocardial c-

fos gene expression was detected with reverse transcription polymerase chain reaction(RT-PCR) method. Results: The myocardial enzyme activities in plasma and the myocardial c-fos gene expression in myocardial ischemia model group were obviously higher than those in sham group(P＜ 0.05), after electro-acupuncture treatment, the myocardial enzyme activities in plasma and the myocardial c-fos gene expression were decreased,there was a significant difference (P＜ 0.05). Conclusion: The mechanism of improvement effect of electro-acupuncture at acupoint Neiguan (PC 6) on AMI is related to down-regulation of the myocardial c-fos mRNA expression. 【总页数】4页(132-135)

【关键词】电针;穴,内关;心肌缺血;基因表达 【作者】谢芳;梁勋厂;吴红金;茹立强;朱忠春 【作者单位】无 【正文语种】中文 【中图分类】R245.9 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_journal-acupuncture-tuina-science_thesis/0201220786193.html 【相关文献】

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