蛋白酶切位点

Enzymes . Number Cleavage sites （丝氨酸蛋白酶） 胰凝乳蛋白酶，糜 蛋白酶) . Tyr-|-Xaa,Trp-|-Xaa, Phe-|-Xaa, and alsoLeu-|-Xaa,Met-|-Xaa, Trypsin (胰朊酶，胰蛋白酶) Pancreatic elastase (胰弹性蛋白酶) . . Arg-|-Xaa, Lys-|-Xaa, Ala-|-Xaa,andalsoGly-|-Xaa, Val-|-Xaa, Ser-|-Xaa, Thrombin(凝血酶) Plasmin(胞质素，胞浆素) Prolyl oligopeptidase,or prolylendopeptidase Plasma kallikrein (血浆激肽释放酶) . Arg-|-Gly, . . Lys-|-Xaa,>Arg-|-Xaa . Arg-|-Xaa, Lys-|-Xaa,including Arg-|-Ser,Lys-|-Arg, Leukocyteelastase(白细胞弹性蛋白酶),orneutrophilelastase(中性白细胞弹性蛋白酶),orlysosomalelastase(溶酶体弹性蛋白酶) Cysteine proteases（半胱氨酸蛋白酶） B (组织蛋白酶) . Val-|-Xaa, Ala-|-Xaa, . Arg-Arg-|-Xaa,and Leu-|-Xaa, Ala-|-Xaa, Phe-|-Xaa, Trp-|-Xaa, also Clostripain(梭菌蛋白酶),or . Arg-|-Xaa including

endoproteinase Arg-C Arg-|-Pro,but not Lys-|-Xaa Calpain(钙激活中性蛋白酶)-1,or μ-calpain . Met-|-Xaa,Tyr-|-Xaa and Arg-|-Xaa(with LeuorVal as the P2 residue) Aspartic acid proteases (天冬氨酸蛋白酶) 胃朊酶，胃蛋白酶) . Preferentially Tyr-|-Xaa, And also Leu-|-Xaa,and Trp-|-Xaa, ideally with Xaa= Phe,Trp,orTyr Phe-|-Xaa, Cathepsin(组织蛋白酶)D . Preferentially Tyr-|-Xaa, Phe-|-Xaa, And also Leu-|-Xaa,ideally with Xaa ≠AlaorVal Metalloproteases （金属蛋白酶） Xaa-|-Tyr,Xaa-|-Phe, Xaa-|-Trp,and Xaa-|-Leu, Thimet oligopeptidase(甲拌磷寡肽 酶),or . endo-oligopeptidase pz-peptidease(肠促胰 酶素) Aminopeptidases （氨肽酶） Leucyl-aminopeptidase . N-term Preferentially Leu-|-Xaa,but not Arg-|-Xaa,andLys-|-Xaa, Aminopeptidase M or N,or alanyl . aminopeptidase,or

脑啡肽酶),or enkephalinase(脑啡肽酶),or . neutralendopeptidase Xaa-|-Arg, Xaa-|-Ser,Xaa-|-Ile, Xaa-|-Ala, Xaa-|-Gly, A,or endopeptidase(肽链内切 酶),or Preferentially Ala-|-Xaa,and membrane alanine Tyr-|-Xaa,if Yaa-Pro-|-Xaa in

aminopeptidase term with Yaa=Ala,Val,Leu,Ile,Phe,Tyr or Trp,then the dipeptide Yaa-Pro could be released Aminopeptidase B AminopeptidaseA,or . Arg-|-Xaa, Lys-|-Xaa, angiotensinase,or . Glu-|-Xaa>>Asp-|-Xaa, glutamyl-aminopeptidase Dipeptidyl-peptidases 肽基肽酶） Dipeptidyl-peptidaseI,or cathepsin(组织蛋白酶)C or J . Xaa-Yaa-|-Zaa,if ArgorLys,or Yaa ≠Pro,orZaa≠Pro Dipeptidyl-peptidase IV . Preferentially Xaa-Pro-|-Zaa,(but Hyp Prolyl tripeptyl-peptidase Peptidyl-Dipeptidases（肽基 - 二肽酶） Peptidyl-depeptidaseA, angiotensin-converting enzyme . Xaa-Yaa-Pro-|-Zaa,if Zaa≠Pro C-term Xaa-|-Yaa-Zaa,if Yaa≠Pro or Zaa≠ Asp or Glu Metallo-carboxypeptidases（金属羧肽酶） Carboxypeptidase A . C-term Xaa-|-Yaaif Yaa ≠also Xaa-Ala-|-Yaa)withYaa ≠Pro or Xaa≠and N-term(di-and tripeptides) tripeptidyl-peptidases （二肽基肽酶和三or . Asp,Glu,Arg,Lys or Pro Carboxypeptidase B,or protaminase . Xaa-|-ArgandXaa-|-Lys Xaa-|-Lys>> Xaa-|-Arg Carboxypeptidase N,or Lysine(arginine), . Carboxypeptidase(羧基肽酶),or kininase

I(激肽酶) Carboxypeptidase U or R . Xaa-|-Arg and Xaa-|-Lys Xaa-|-Glu,preferentially Xaa= Asp or Glu

with Glutamate CarboxypeptidaseII,or folate . hydrolase