肥胖相关肾病发病机制与临床研究进展
吴睿;王锋;汪年松
【期刊名称】《中华肾病研究电子杂志》 【年(卷),期】2016(005)001
【摘要】In the last 20 years,the population of overweight and obesity has been growing rapidly. And obesity-related glomerulopathy (ORG),which can be directly induced by obesity,has received more and more attention.The pathogenesis of ORG is complex,including hemodynamic
dysfunction,kidney
hypoxia,insulin
resistance,over-
activation of sympathetic nerve,and so on,in which podocyte injury appears to play a central role.The typical renal histologic features of ORG
consisted
of
simple
obesity-associated
focal
glomerular segmental
hypertrophy,and obesity-associated
glomerulosclerosis.The most striking clinical characteristic of ORG is the existence of massive proteinuria with very low incidence of nephrotic syndrome.The treatment for ORG mainly aims at the proper control of the associated risk factors, such as weight control,ameliorating insulin resistance,inhibiting over-activation of RAAS,etc,in order to delay the deterioration of renal functions.%近20年来超重和肥胖人群迅猛增长，而由此诱发的肾脏损害-肥胖相关肾病（ORG）也越来越受到重视。ORG 发病机制复杂，涉及血流动力学障碍、肾组织缺氧、胰岛素抵抗和交感神经过度激活等多种因素，而足细胞损伤在其中发挥核心作用。ORG 病理形态包括两种：单
肥胖相关肾病发病机制与临床研究进展
