四君子汤联合缺血预处理对大鼠肝脏缺血再灌注损伤保护作用的研究

四君子汤联合缺血预处理对大鼠肝脏缺血再灌注损伤保护

作用的研究

华晨;傅永清;傅天啸;周剑;兰菲;任大为

【期刊名称】《浙江实用医学》 【年(卷),期】2014(000)002

【摘要】Objective To investigate the effect of Decoction of Four Mild Drugs with ischemia preconditioning against hepatic is-chemia-reperfusion in rats .Methods 100 SD rats were randomly divided into the SHAM ,the Control ,the Decoction of Four Mild Drugs , the IPC ,the Decoction of Four Mild Drugs + IPC groups .After a Surgery for hepatic ischemia -reperfusion ,the levels of glutamic acid aminotransferase (ALT);Aspartate

aminotransferase

(AST);apoptosis;malondialdehyde

(MDA);superoxide dismutase( SOD ) were mea-sured .Results ALT and AST levels in the the Decoction of Four Mild Drugs+IPC group were significantly lower than those in the Control , the Decoction of Four Mild Drugs and the IPC groups ( P<0.05 ) .ALT and AST levels in the Decoction of Four Mild Drugs and the IPC groups were significantly lower than that in the control group ( P<0.05) .Apoptotic index and MDA level in the the Decoction of Four Mild Drugs+IPC ,the Decoction of Four Mild Drugs and the IPC groups were significantly lower than that in the control group ( P<0.05) .SOD level in the Decoction of Four Mild Drugs +IPC group was significantly higher than those in the other