吲哚布芬治疗急性脑梗死的临床疗效观察
杨琨;孙佳凡
【期刊名称】《中国医药》 【年(卷),期】2012(007)002
【摘要】Objective To investigate the effects and safety of Xinbei- indobufen in patients with acute ischemic stroke disease.Methods A totally of 170 patients with acute ischemic stroke were selected and randomly divided into experiment group ( n =82) and control group ( n =88 ).The patients in experiment group were given anti-platelet indobufen and others in control group were given aspirin for 6 weeks.Platelet aggregation,the score of neurology impairment and adverse effects were compared between the two groups.Results After treatment,the platelet aggregation in both groups was lower at 2-week and 6-weeks than before (P ＜ 0.01 ).The score of neurology impairment in the both groups was improved at the 6-weeks ( P ＜ 0.01 ).There were no significant differences in the platelet aggregation and the score between experiment group and control group (P ＞ 0.05 ).Drug related serious adverse effects were not found in the experiment group.Conclusions Indobufen may reduce significantly platelet aggregation among the patients with acute ischemic stroke.The effect on anti-platelet of indobufen is equal to one of aspirin.Indobufen related adverse effects are seldom and minor.Indobufen is safe in
treating acute ischemic stroke.%目的 探讨吲哚布芬治疗急性脑梗死患者的临床疗效.方法 入选的170例急性脑梗死患者完全随机分为研究组(82例)和对照组(88例),研究组给予吲哚布芬治疗,对照组给予阿司匹林治疗,余治疗同急性脑梗死常规治疗.对2组治疗前及治疗14 d、6周后血小板聚集率[花生四烯酸(AA)诱导法和二磷酸腺苷(ADP)诱导法]、临床症状和不良反应发生率进行比较.结果 研究组、对照组治疗后14 d、6周时血小板聚集率均低于治疗前[研究组:AA
法(15.7±3.5)％、(1 4.8±3.1)％比(37.8±7.7)％,ADP
法
(36.7±7.4)％,(40.5±5.6)％比(88.7±8.6)％；对照组:AA法(16.0±2.9)％、(15.5±3.6)％比(42.6±6.8)％,ADP法(39.2±7.0)％,(37.4±4.9)％比(90.3±7.8)％,P＜0.01]；2组治疗后神经功能缺损评分均有显著性好转(P＜0.01)；2组间治疗后血小板聚集率、临床疗效无明显差异(P＞0.05)；研究组未出现严重的不良反应.结论 吲哚布芬能显著降低血小板聚集率,与阿司匹林相当,在脑梗死急性期时使用安全性较高. 【总页数】2页(144-145)
【关键词】急性脑梗死;吲哚布芬;抗血小板 【作者】杨琨;孙佳凡
【作者单位】030013太原,山西省中西医结合医院神经内科;030013太原,山西省中西医结合医院神经内科 【正文语种】中文 【中图分类】R743 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_china-
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吲哚布芬治疗急性脑梗死的临床疗效观察
