妊娠高血压综合征患者血清可溶性白细胞介素6受体和可
溶性糖蛋白的检测
李雅丽;戚磊;王悦
【期刊名称】《中华妇产科杂志》 【年(卷),期】2001(036)001
【摘要】目的 观察妊娠高血压综合征（妊高征）患者血清可溶性白细胞介素6受体（sIL-6R）和可溶性糖蛋白(sgp130)的变化。方法 应用酶联免疫吸附法（ELISA）检测40例妊高征患者（妊高征组）和20例正常非孕妇女（对照组I）、20例正常妊娠妇女（对照组II）血清sIL-6R和sgp130水平。结果 妊高征组血清sIL-6R为(196.7±12.9) μg/L，sgp130为(379.4±79.3) μg/L；对照组I血清sIL-6R为(174.8±46.2) μg/L，sgp130为(273.6±28.3) μg/L；对照组II血清sIL-6R为(174.4±48.3) μg/L，sgp130为(254.4±34.7) μg/L。妊高征组血清sIL-6R和sgp130水平均高于对照组I和对照组II，差异有极显著性（P<0.01）。妊高征组中，随病情加重，血清sIL-6R、sgp130水平逐渐升高。差异有极显著性（P<0.01）。对照组II血清sIL-6R和sgp130水平与对照组I比较，差异无显著性（P>0.05）。结论 血清sIL-6R和sgp130水平变化与妊高征的病情发展有关。%Objective To observe the changes of serum soluble interleukin-6 receptor (sIL-6R) and soluble gp130 (sgp130) in patients with pregnancy induced hypertension. Methods Enzyme linked immunosorbent assay (ELISA) was used to determine serum sIL-6R and sgp130 levels in 40 patients with pregnancy induced hypertension (study group), 20 normal non-pregnant women (control
group I) and 20 normal pregnant women (control group II). Results In study group, sIL-6R was (196.7±12.9) μg/L and sgp130 was (379.4±79.3) μg/L. In control group I, sIL-6R was (174.8±46.2) μg/L and sgp130 was (273.6±28.3) μg/L. In control group II, sIL-6R was (174.4±48.3) μg/L and sgp130 was (254.4±34.7) μg/L. SIL-6R and sgp 130 were higher in study group than those in control groups with significant difference (P<0.01). In study group, the more severe the patients, the higher the sIL-6R and sgp130 levels. There was significant difference (P<0.01). There was no difference in sIL-6R and sgp130 levels between control groups (P>0.05). Conclusions Serum sIL-6R and sgp130 levels are related to the development of pregnancy induced hypertension. 【总页数】2页(18-19)
【关键词】妊娠并发症,心血管;高血压;受体,白细胞介素-6;抗原P150,95 【作者】李雅丽;戚磊;王悦
【作者单位】河南省人民医院妇产科;河南医科大学第二附属医院检验科;河南省人民医院妇产科 【正文语种】中文 【中图分类】R71 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-obstetrics-gynecology_thesis/0201236267789.html 【相关文献】
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妊娠高血压综合征患者血清可溶性白细胞介素6受体和可溶性糖蛋白的检测
