非诺贝特对伴高甘油三酯血症糖代谢异常患者胰岛β细胞
功能和胰岛素抵抗的影响
许雯;李月霞;刘娟;邓婉萍;李延兵
【期刊名称】《中华全科医师杂志》 【年(卷),期】2010(009)009
【摘要】Thirty six patients with hypertriglyceridemia and impaired glucose regulation or newly diagnosed type 2 diabetes, whose fasting plasma glucose was ≤8.0 mmol/L, were treated by fenofibrate for 3 months. Lipid profile, insulin during intravenous glucose tolerance test and oral glucose tolerance test ( including glucose) were measured before and after treatment After treatment, lipid profile was significantly improved. Insulinogenic index (△I30/△G30) and acute insulin response were significantly increased (98. 9vs. 129. 2, 3558.9 vs. 4783. 3 pmol · L - 1 · min - 1, respectively, P ＜ 0. 05 ). Fasting insulin and insulin resistant index in homeostasis model assessment ( HOMA IR) decreased ( 128. 6 vs. 84. 8 pmol/L, 4. 8 vs.3.0, respectively, P ＜0. 05 ). The improvement of insulin secretory function was more significant in patients with higher triglyceride (TG ＞ 3. 3 mmol/L). These results indicate that short-term lipid-lowering treatment with fenofibrate can improve β-cell function and insulin resistance. Patients with higher triglyceride are likely to achieve more benefit from lipid-lowering treatment.%对36例高甘油三酯(TG)并糖调节受损或空腹血糖≤8.0 mmol/L新诊断2型糖尿病患者,行3个月
非诺贝特治疗.治疗后患者血脂水平改善,早时相胰岛素生成指数及急性胰岛素反应增加(98.9比129.2,3558.9比4783.3 pmol·L-1·min-1,均P＜0.05);空腹胰岛素、稳态模型胰岛素抵抗指数显著下降(128.6比84.8 pmol/L,4.8比3.0,均P＜0.05);TG高值组(TG＞3.3 mmol/L)治疗后胰岛β细胞功能改善更为明显.说明非诺贝特短期调脂治疗可改善胰岛β细胞功能、减轻胰岛素抵抗,TG水平高者获益更明显.
【总页数】3页(645-647)
【关键词】高甘油三酯血症;普鲁脂芬 【作者】许雯;李月霞;刘娟;邓婉萍;李延兵
【作者单位】510080,广州,中山大学附属第一医院内分泌科;郑州大学附属第一医院重症监护室;510080,广州,中山大学附属第一医院内分泌科;510080,广州,中山大学附属第一医院内分泌科;510080,广州,中山大学附属第一医院内分泌科 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-general-practitioners_thesis/0201254612460.html 【相关文献】
1.非诺贝特对高甘油三酯血症人群胰岛素抵抗和胰岛β细胞分泌功能的影响 [J], 梁真; 严励; 李焱; 黎锋; 戚以勤; 蔡梦茵; 程桦
2.非诺贝特改善伴高甘油三酯糖代谢异常患者急性胰岛素分泌反应 [J], 刘娟; 李月霞; 许雯; 邓婉萍; 李延兵
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非诺贝特对伴高甘油三酯血症糖代谢异常患者胰岛β细胞功能和胰岛
