HSPA9在肝细胞肝癌的表达和临床意义
康强;邹浩;刘立鑫;赵松凌;张维瀚;张小文
【期刊名称】《重庆医学》 【年(卷),期】2017(046)017
【摘要】Objective To investigate the expression of HSPA9 in hepatocellular
carcinoma(HCC)
and
its
relationship
with
clinicopathological features and prognosis.Methods Forty-nine cases HCC treated by operative resection and follow up data in our hospital from
January
2006
to
January
2010
were
retrospectively
analyzed.Immunohistochemistry was performed to determine the expression of HSPA9 in HCC and paratumor tissues.The relationship between HSPA9 expression and clinicopathological features and prognosis was statistically analyzed.Results The HSPA9 protein expression in tumor tissue was higher that that in the paratumor tissue(t=6.601,P＜0.01),moreover the over expression of HSPA9 was significantly correlated with lymph node metastasis (P =0.005),TNM-stage(P =0.015),tumor differentiation (P =0.033),microvascular invasion (P =0.009) and recurrence (P =0.047).In the survival analysis results,the patients with over expression of HSPA9 had a much lower total survival rate(P=0.002)and much higher postoperative cumulative recurrence rate(P
=0.003).There
were
significant
differences node
in
TNM-
stage,microvascular invasion,lymph metastasis,tumor
HSPA9在肝细胞肝癌的表达和临床意义
