Target Organ Protection from a Novel Angiotensin Ⅱ Receptor (AT1) Vaccine ATR12181 in Sp

Target Organ Protection from a Novel Angiotensin

Ⅱ Receptor (AT1) Vaccine ATR12181 in Spontaneously Hypertensive Rats

Feng Zhu;Yuhua Liao;Liudong Li;Min Cheng;Fen Wei;Yumiao Wei;Ming Wang

【期刊名称】《中国免疫学杂志（英文版）》 【年(卷),期】2006(003)002

【摘要】Hypertension produces pathophysiological changes that are often responsible for the mortality associated with the disease. It is evident that overactive renin-angiotensin systems play a central role in the development of hypertension and target organ damage associated with hypertension. We have previously found that a novel angiotensin Ⅱ receptor (AT1) vaccine-ATR12181 attenuated the development of high blood pressure (BP) in spontaneously hypertensive rat (SHR) model of human essential hypertension. Our objective was to determine whether this attenuation of high BP is associated with prevention of target organ damage induced by hypertensive state. SHRs were immunized against a peptide (coded ATR12181) from the extracelluar portion of the AT1A receptor by repeated subcutaneous injections of peptide-tetanus-toxoid complex in combination with Freund's adjuvant. A 64 weeks long-term observation was performed. Repeated vaccinations resulted in the induction of anti-ATR12181 antibodies. At the end of observation, vaccinated SHRs manifested lower BP, decreased

cardiac hypertrophy and attenuation of kidney injuries. mRNA levels of c-fos and c-jun in heart and kidneys were decreased in vaccinated SHRs. Since a self antigen was used, safety of vaccine was concerned. However, the signs of autoimmune diseases were not observed in the sections of heart and kidney. These data demonstrated that repeated immunization against a domain of the extracellular portion of the AT1 receptor was able to cause a target organ protection against hypertension. Active immunization against the AT1 receptor may be considered as a promising new strategy in the treatment of hypertension. 【总页数】8页(107-114)

【关键词】AT1, hypertension, vaccine, immune system

【作者】Feng Zhu;Yuhua Liao;Liudong Li;Min Cheng;Fen Wei;Yumiao Wei;Ming Wang

【作者单位】Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong Science & Technology University, Wuhan 430022, China;Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong Science & Technology University, Wuhan 430022, China;Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong Science & Technology University, Wuhan 430022, China;Laboratory of Cardiovascular Immunology, Institute of Cardiology,

Union Hospital, Tongji Medical College, Huazhong Science & Technology

University,

Wuhan

430022,

China;Laboratory

of

Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong Science & Technology University, Wuhan 430022, China;Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong Science & Technology University, Wuhan 430022, China;Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong Science & Technology University, Wuhan 430022, China 【正文语种】中文 【中图分类】R3 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_cellular-molecular-immunology_thesis/0201224013509.html 【相关文献】

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