Insulinotrophic and hypolipidemic effects ofEcklonia cava in streptozotocin-induced diabetic mice

Insulinotrophic and hypolipidemic effects ofEcklonia cava in streptozotocin-induced diabetic

mice

Mi-Ja Kim;Hye Kyung Kim

【期刊名称】《亚太热带医药杂志（英文版）》 【年(卷),期】2012(000)005

【摘要】ABSTRACT Objective:To explore the anti-diabetic activity ofEcklonia cava (EC) in streptozotocin (STZ)-induced diabetic mice.Methods:Diabetes was induced by a single intraperitoneal injection of STZ(90 mg/kg). Normal and diabetic mice were treated with0%, 3%, and5% ECdiet for4 weeks. Serum glucose and insulin concentrations, serum lipid profile, oral glucose tolerance test, and liver and pancreatic β-cell histopathological observations were performed. In addition,in vitro glucose-induced insulin secretion was determined using pancreatic β-islet cells.Results:EC supplementation significantly and dose-dependently decreased serum glucose concentration, and improved glucose homeostasis in diabetic mice by preventing loss of β-cell mass resulting in increase of insulin secretion. The triglyceride and total cholesterol concentrations in the serum and liver were markedly reduced byEC treatment inSTZ-diabetic mice. Moreover,LDL-, and HDL-cholesterol levels were ameliorated inEC supplemented diabetic mice. Liver steatosis induced by STZ was ameliorated byEC supplementation.