Preliminary phytochemical, acute oral toxicity and antihepatotoxic study of roots of Paeon

Preliminary phytochemical, acute oral toxicity and

antihepatotoxic study of roots of Paeonia

officinalis Linn

Feroz Ahmad;Nahida Tabassum

【期刊名称】《亚太热带生物医学杂志（英文版）》 【年(卷),期】2013(000)001

【摘要】Objective: To carry out a preliminary phytochemical, acute oral toxicity and antihepatotoxic study of the roots of Paeonia officinalis (P. officinalis) L. Methods: Preliminary phytochemical investigation was done as per standard procedures. Acute oral toxicity study was conducted as per OECD 425 guidelines. The antihepatotoxic activity of aqueous extract of root of P. officinalis was evaluated against carbon tetrachloride (CCl4) induced hepatic damage in rats. Aqueous extract of P. officinalis at the dose levels of 100 and 200 mg/kg body weight was administered daily for 14 d in experimental animals. Liver injury was induced chemically, by CCl4 administration (1 mL/kg i.p.). The hepatoprotective activity was assessed using various biochemical parameters

like

aspartate

aminotransferase

(AST),

alanine

aminotransferase (ALT), serum alkaline phosphatase (SALP), total bilirubin and total protein (TP) along with histopathological studies. Result: Phytochemical screening revealed that the roots ofP. officinalis contain alkaloids, tannins, saponins, glycosides, carbohydrates,