Product Data?SheetDihydroethidiumCat. No.:CAS No.:分?式:分?量:作?靶点:作?通路:储存?式:HY-D0079104821-25-2C??H??N?315.41OthersOthers4°C, protect from light* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)Inhibitors?Agonists?Screening Libraries溶解性数据体外实验DMSO : ≥ 50 mg/mL (158.52 mM)H2O : < 0.1 mg/mL (insoluble)* \Mass1 mg5 mg10 mgSolventConcentration制备储备液1 mM5 mM10 mM3.1705 mL0.6341 mL0.3170 mL15.8524 mL3.1705 mL1.5852 mL31.7048 mL6.3410 mL3.1705 mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；?旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存?式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个?内使?，-20°C 储存时，请在 1 个?内使?。体内实验请根据您的实验动物和给药?式选择适当的溶解?案。以下溶解?案都请先按照 In Vitro ?式配制澄清的储备液，再依次添加助溶剂： 为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的?作液，建议您现?现配，当天使?； 以下溶剂前显?的百分?是指该溶剂在您配制终溶液中的体积占?；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的?式助溶1. 请依序添加每种溶剂：?10% DMSO ?? 40% PEG300 ?? 5% Tween-80 ?? 45% salineSolubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution此?案可获得 ≥ 2.5 mg/mL (7.93 mM，饱和度未知) 的澄清溶液。 以 1 mL ?作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加? 50 μL Tween-80，混合均匀；然后继续加? 450 μL ?理盐?定容? 1 mL。BIOLOGICAL ACTIVITYPage 1 of 2
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?物活性Dihydroethidium(Hydroethidine; PD-MY 003)是过氧化物指?剂，在细胞质中具有蓝?荧光，直到被氧化。
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????Cell Death Dis.?2020 Apr 20;11(4):256.?
????Journal of Zhengzhou University. 2018 (02): 147-150.See more customer validations on www.MedChemExpress.cnREFERENCES
[1].?Zielonka J, et al. Global profiling of reactive oxygen and nitrogen species in biological systems: high-throughput real-time analyses. J Biol Chem. 2012 Jan 27;287(5):2984-95.
[2].?Kwong C, et al. Tumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes. J Immunol. 2011 Feb 1;186(3):1781-9.
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