Synthesis and Structural Studies of 1-Deoxybaccatin VI Derivatives

Synthesis and Structural Studies of 1-Deoxybaccatin VI Derivatives

LIN,Hai-Xia;WANG,Dian-Long;CHEN,Jian-Min;CHEN,Min-Qin

【期刊名称】《中国化学（英文版）》 【年(卷),期】2008(026)010

【摘要】Synthesis and crystal structures of 1-deoxybaccatin VI derivatives, and the influence of C(9), C(10), and C(13) substituents of the tetracyclic moiety on molecular conformations were investigated. Comparison of conformations of 1-deoxybaccatin VI derivatives reveals subtle conformational variations in the tetracyclic ring system due to deacetylation at C(10) and C(13), and 9,10-acetonide. Additionally, C(2)-benzoyl group exhibits an unexpected conformational flexibility in 1-deoxybaccatin VI derivatives, which may be relevant to the bioactivity of taxanes.

【总页数】9页(1870-1878)

【关键词】1-deoxybaccatin VI derivative, crystal structure, conformation, paclitaxel, synthesis

【作者】LIN,Hai-Xia;WANG,Dian-Long;CHEN,Jian-Min;CHEN,Min-Qin 【作者单位】Department of Chemistry,Shanghai University,Shanghai 200444,China;Department of Chemistry,Shanghai University,Shanghai 200444,China;Department

of

Environmental

Science

&

Engineering,Fudan University,Shanghai 200433,China;Research Center of

Analysis and Measurement,Fudan University,Shanghai 200433,China 【正文语种】中文 【中图分类】O6 【相关文献】

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