木犀草素对大鼠脑缺血后 TRAF6表达的影响及其保护作用
机制研究
乔会敏;李震中;郭书英;杜媛媛;陈林玉;张祥建
【期刊名称】《脑与神经疾病杂志》 【年(卷),期】2015(000)006
【摘要】Objective This study is to evaluate the changes of tumour-necrosis factor receptor-associated factor 6 ( TRAF6) after cerebral ischemia and to explore the underlying mechanisms of luteolin.Methods Male Sprague-Dawley rats were subjected to permanent middle cerebral occlusion ( MCAO ) .Luteolin was systemically administered to explore the effect on TRAF6 at 24 h after cerebral ischemia by western blot.The infarct volume, brain water content, and neurological deficits were measured.Results The expression of TRAF6 was up-regulated at 24h after cerebral ischemia (2.14±0.05).Luteolin down-regulated TRAF6 expression induced by cerebral ischemia (P<0.05 ) .Meanwhile, luteolin dramatically alleviated neurological deficit, brain water content and infarct volume ( P<0.05) .Conclusion Luteollin can protect the brain from the damage caused by ischemia, whose neuroprotection effect may be through downregulation of TRAF6.%目的：观察脑缺血后肿瘤坏死因子受体相关因子6（ TRAF6）的表达变化，探讨木犀草素的脑保护机制研究。方法用线栓法制作大鼠大脑中动脉（ MCAO）闭塞模型。采用Western blot观察TRAF6蛋白变化，比较各组脑梗死体积、患侧脑水肿和神经功能缺损评分。结
木犀草素对大鼠脑缺血后 TRAF6表达的影响及其保护作用机制研究
