慢性阻塞性肺疾病患者急性加重期细胞因子的变化及沙美
特罗替卡松的治疗效果
何卫
【期刊名称】《中国医药导报》 【年(卷),期】2012(009)016
【摘要】Objective To explore the change of cytokines in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and the clinical effect of Salmeterol and Fluticasone. Methods 210 cases of COPD were selected as research subjects, including 120 patients of AECOPD and 90 cases of stable COPD. 120 cases of AECOPD were randomly divided into control group and experience group, each group had 60 cases. Control group were given Salbutamol by nebulization, and experience group received inhalation of Salmeterol and Fluticasone. Results hs-CRP, IL-8 and TNF-a in AECOPD patients were significantly higher than that in stable COPD patients (P < 0.01); FEV1 and FEV1/FVC were greatly decreased in AECOPD patients (P< 0.01); The level of hs-CRP、IL-8、TNF-otwere all decreased in experience group and control group after treatment (P < 0.05); But the cytokines level of experience group was much lower than that of control group, and FEV1, FEV1/FVC was superior to control group (P < 0.05). Conclusion Cytokines level is significantly increased in AECOPD patients. Salmeterol and Fluticasone can greatly decrease the cytokines level and improve lung function.%目
慢性阻塞性肺疾病患者急性加重期细胞因子的变化及沙美特罗替卡松
