A high strength,anti-fouling,self-healable,and thermoplastic supramolecular polymer hydrog
A high strength,anti-fouling,self-healable,and thermoplastic supramolecular polymer hydrogel
with low fibrotic response
作者:WANG HongBo[1];LI HaoFei[1];WU YuanHao[1];YANG JianHai[1];LIU WenGuang[1];
作者机构:[1]School of Materials Science and Engineering,Tianjin Key Laboratory of Composite and Functional Materials,Tianjin
University,Tianjin 300350,China;[1]School of Materials Science and Engineering,Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University,Tianjin 300350,China;[1]School of Materials Science and Engineering,Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University,Tianjin 300350,China;[1]School of Materials Science and Engineering,Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University,Tianjin
300350,China;[1]School of Materials Science and Engineering,Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University,Tianjin 300350,China; 来源:中国科学 年:2019 卷:062 期:004
页码:P.569-577 页数:9 中图分类:TH 正文语种:CHI
关键词:supramolecular polymer hydrogel;self-healing;anti-protein absorption;fibrotic response
摘要:The fibrotic response plays an important role in the performance and longevity of implantable devices.Thus,development of effective anti-inflammatory and anti-fibrosis biomaterial implants has become an urgent task.In this work,we developed a novel supramolecular polymer hydrogel through the copolymerization of N-acryloyl
glycinamide(NAGA)and carboxybetaine acrylamide(CBAA)in the absence of any chemical crosslinker,which the mechanical properties being tunable through changing the monomer concentration and the monomer ratio over a broad scope.The hydrogel possessed the superior mechanical performances:high tensile strength(~1.13 MPa),large stretchability(~1200%),and excellent compressive strength(~9 MPa)at high monomer concentration and NAGA/CBAA ratio.Introduction of CBAA could promote the self-healability,thermoplasticity of
suparmolecular polymer hydrogels at lower temperatures,meanwhile dramatically improving anti-fouling property.Histological analysis and in vitro cytotoxicity assays testified the excellent biocompatibility of the hydrogel.This high strength supramolecular polymer hydrogel with integrated multiple functions holds promising potentials as a scaffold biomaterial for treating degenerated soft supporting tissues.
A high strength,anti-fouling,self-healable,and thermoplastic supramolecular polymer hydrog
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