Pefabloc- A sulfonyl fluoride serine protease inhibitor blocks induction of Diptericin in
Pefabloc- A sulfonyl fluoride serine protease inhibitor blocks induction of Diptericin in
Drosophila I(2)mbn cells
Karin C.Johansson;Kenneth S(o)derh(a)ll;Maria I.Lind
【期刊名称】《中国昆虫科学：英文版》 【年(卷),期】2012(019)004
【摘要】Insects protect themselves against microbial infection by an efficient innate immune system that is activated by recognition of invariant microbial surface molecules.In the fruit fly Drosophila melanogaster the presence of bacteria is associated with expression ofantimicrobial peptides in host immune-competent tissues.Host receptors detect infection and relay the signal to mount the appropriate immune response.In Drosophila hemocytelike I(2)mbn cells pre-infection treatment with Pefabloc,a commonly used scrine protease inhibitor,induced two major effects:it blocked expression of the antibacterial peptide Diptericin in response to live Gram-negative bacteria and bacterial surface molecules (crude lipopolysaccharide contaminated by peptidoglycans) and it induced morphological changes.
【总页数】5页(472-476) 【关键词】
【作者】Karin C.Johansson;Kenneth S(o)derh(a)ll;Maria I.Lind
Pefabloc- A sulfonyl fluoride serine protease inhibitor blocks induction of Diptericin in
