Imbalance of Fecal Microbiota at Newly Diagnosed Type 1 Diabetes in Chinese Children

Imbalance of Fecal Microbiota at Newly Diagnosed

Type 1 Diabetes in Chinese Children

Cui-Juan Qi;Qian Zhang;Miao Yu;Jian-Ping Xu;Jia Zheng;Tong Wang;Xin-Hua Xiao

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2016(129)011

【摘要】Background:Recent studies have indicated that an imbalance of gut microbiota is associated with the development of type 1 diabetes mellitus (T1DM) and there is no literature regarding it in Chinese children yet.The aim of this study was to evaluate the alteration of gut microbiota between children with newly diagnosed T 1DM and healthy controls and to determine if gut microbiota could partly explain the etiology of this disease.Methods:A case-control study was carried out with 15 children with T 1DM and 15 healthy children.The fecal bacteria composition was investigated by high-throughput sequencing of the V3-V4 region of the 16S rDNA gene and analyzed by the estimators of community richness (Chao) indexes.Results:There was a notable lower richness of fecal bacteria in T 1DM group than controls (156.53 ± 36.96 vs.130.0 ± 32.85,P =0.047).At the genus level,the composition of Blautia was increased in T 1DM group than control group whereas the composition of Haemophilus,Lachnospira,Dialister,and Acidaminococcus was decreased.In addition,we found that the percentage of Blautia was correlated positively with HbAlc (p =0.40,P =0.031),the numbers of