Gut Microbiota-brain Axis
Hong-Xing Wang;Yu-Ping Wang
【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2016(129)019
【摘要】Objective:To systematically review the updated information about the gut microbiota-brain axis.Data Sources:All articles about gut microbiota-brain axis published up to July 18,2016,were identified through a literature search on PubMed,ScienceDirect,and Web of Science,with the keywords of\microbiota\axis\\Selection:All relevant articles on gut microbiota and gut-brain axis were included and carefully reviewed,with no limitation of study design.Results:It is well-recognized that gut microbiota affects the brain's physiological,behavioral,and cognitive functions although its precise mechanism has not yet been fully understood.Gut microbiota-brain axis may include gut microbiota and their metabolic products,enteric nervous system,sympathetic and parasympathetic branches within the autonomic nervous system,neural-immune
system,neuroendocrine
system,and
central
nervous
system.Moreover,there may be five communication routes between gut microbiota
and
brain,including
the
gut-brain's
neural axis,gut
network,neuroendocrine-hypothalamic-pituitary-adrenal
immune system,some neurotransmitters and neural regulators
Gut Microbiota-brain Axis
