顺铂在玻碳电极上的电化学行为及其测定的研究

顺铂在玻碳电极上的电化学行为及其测定的研究

放茂良;李乔丽;刘琼;贝玉祥;高云涛

【期刊名称】《药物分析杂志》 【年(卷),期】2011(031)006

【摘要】Objective:To investigated the electrochemical behavior and determination of cisplatin at glassy carbon electrode. Methods: Cyclic voltammetry and differential pulse voltammetry. Results : One pair of quasi - reversible redox peaks of cisplatin was obtained at glassy carbon electrode by cyclic voltammetry with 0. 78 V of Epa and 0. 3 V of Epc , △E =0. 48 V , and Ipa/Ipc =4. 30. Under optimal condition, the oxidization peak was linearly related to the concentration of cisplatin in the rang of 6. 54 × 10 -5 -3. 03 × 10 -4 mol · L-1 with the detection limit of 3. 9 × 10 -5 mol · L -1. Conclusion : This method was convenient, accurate, credible and sensitive,it can be used in the determination of cisplatin.%目的:研究顺铂在玻碳电极上的电化学行为及其测定方法.方法:循环伏安法(CV)和差分脉冲伏安法(DPV).结果:顺铂在玻碳电极上有一对准可逆氧化还原峰,氧化峰电位

Epa

与还原峰电位

Epc

分别为

0.78,0.3V,△E=0.48V,Ipa/Ipc=4.30.在优化条件下,顺铂的氧化峰电流与其浓度在6.54×10-5～3.03×10-4mol·L-1范围内成良好的线性关系(r=0.9978),检出限为3.9×10-5 mol·L-1.结论:本方法操作简便.准确可靠,灵敏度高,可用于顺铂含量的直接测定.

【总页数】3页(1165-1167)