Deep Brain Stimulation of the Globus Pallidus Internus in Patients with Intractable Touret

Deep Brain Stimulation of the Globus Pallidus Internus in Patients with Intractable Tourette

Syndrome: A 1-year Follow-up Study

Xiao-Hua Zhang;Jian-Yu Li;Yu-Qing Zhang;Yong-Jie Li

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2016(129)009

【摘要】Background:Deep brain stimulation (DBS) has been a promising treatment for patients with refractory Tourette syndrome (TS) for more than a decade.Despite successful DBS treatment of TS in more than 100 patients worldwide,studies with a large patient sample and long-term follow-up assessments are still scarce.Accordingly,we investigated the clinical efficacy and safety of globus pallidus internus (GPi) DBS in the treatment of intractable TS in 24 patients with a l-year follow-up assessment.Methods:Bilateral/unilateral GPi-DBS was performed in 24 patients with TS.We evaluated symptoms of tics and obsessive-compulsive disorder (OCD) through the Yale Global Tic Severity Scale (YGTSS) and Yale-Brown Obsessive-compulsive Scale (Y-BOCS).We used the Wechsler Adult Intelligence Scale-Revised in China (WAIS-RC) to evaluate the safety of the treatment.We conducted follow-up assessments of all patients for at least 12 months (12-99 months).Results:Symptoms of tics and OCD were significantly relieved at a 12-month follow-up assessment.The mean YGTSS score was 74.04 ±