IL-10-Producing Type 1 Regulatory T Cells and
Allergy
Kui Wu;Yutian Bi;Kun Sun;Changzheng Wang
【期刊名称】《中国免疫学杂志（英文版）》 【年(卷),期】2007(004)004
【摘要】As an important subset of regulatory T (Treg) cells, IL-10-producing type 1 regulatory T cells (Tr1), have some different features to thymic-derived naturally occurring CD4+CD25+Foxp3+ Treg cells(nTreg cells). Similar to nTreg cells, Tr1 also play important roles in the control of allergic inflammation in several ways. There is a fine balance between Tr1 and Th2 responses in healthy subjects. Skewing of allergic-specific effctor T cells to a Tr1 phenotype appears to be a critical event
in
successful
allergen-specific
immunotherapy
and
glucocorticoids and β2-agonists treatment. Tr1 suppress Th2 cells and effector cells of allergic inflammation, such as eosinophils, mast cells, basophils, through producing IL-10, and perhaps TGF-β. Understanding of Tr1 may be helpful in developing new strategies for treatment of allergic diseases. 【总页数】7页(269-275)
【关键词】allergic disease, immune dysregulation, interleukin 10, regulatory T cell, type 1 regulatory T cell
【作者】Kui Wu;Yutian Bi;Kun Sun;Changzheng Wang
【作者单位】Department of Respiratory Disease, Daping Hospital, Third Military Medical University, Chongqing 400042, China;Department of Respiratory Disease, Daping Hospital, Third Military Medical University, Chongqing 400042, China;Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China;Institute of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China 【正文语种】中文 【中图分类】R3 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_cellular-molecular-immunology_thesis/0201223934056.html 【相关文献】
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IL-10-Producing Type 1 Regulatory T Cells and Allergy
