多学科综合治疗儿童神经母细胞瘤的临床疗效评估
安霞;袁晓军;蒋马伟;谈珍;李玉华;王立峰;吴晔明
【期刊名称】《中华小儿外科杂志》 【年(卷),期】2015(036)001
【摘要】Objective To explore the effects of multidisciplinary treatment on clinical features and outcomes of children with neuroblastoma and provide rationales for optimized treatment.Methods A total of 95 neuroblastoma patients enrolled into our hospital from January 2007 to December 2012 were retrospectively analyzed.Their median age at diagnosis was 31.6 (1.1-159.8) months,male to female ratio 1.6:1 and median follow-up time 32 (13-80) months.Advanced neuroblastoma of International Neuroblastoma Staging System stages Ⅲ &-Ⅳ accounted for 66.3％ (63/95).Results According to different risk groups,all patients received
intensive
chemotherapy,surgery,radiotherapy,autologous
hematopoietic stem cell transplantation (ASCT) and 13-cis-retinoid for induced differentiation therapy.Estimated 5-year overall survival (5y-OS) was 67.2％ ± 5.3％ and event-free survival (5y-EFS) 57.8％ + 5.5％.The 5y-OS was 100％ for stage Ⅰ,100％ for stage Ⅱ,63.6％ ± 14.5％ for stage Ⅱ and 46.9％ + 8.3％ for stage Ⅲ.And the 5y-EFS was 92.3％ + 7.4％ for stage Ⅰ,100％ for stage],42.4％ + 19.8％ for stage Ⅲ and 35.4％ + 7.8％ for stage Ⅳ.The prognosis of low-riskers and middle-riskers was much better than that of high-riskers and very-high-riskers (P＜
多学科综合治疗儿童神经母细胞瘤的临床疗效评估
