新诊断2型糖尿病患者血清25-羟维生素D3的临床意义
程亮;俞伟男;胡文;柏凤;郝海荣
【期刊名称】《医学研究杂志》 【年(卷),期】2013(042)008
【摘要】目的 观察新诊断2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清25-羟维生素D3[25-hydroxy vitamin D3,25(OH)D3]水平的变化,分析血清25(OH)D3在新诊断T2DM患者中的意义.方法 通过比较118例新诊断T2DM患者与60例健康体检者血糖、血脂、胰岛素抵抗指数(homeostasis model assessment insulin resistance index,HOMA-IR)、胰岛β细胞功能指数(homeostasis model assessment islet β-cell function index,HOMA-β)及25(OH)D3等方面的差别,并分析25(OH)D3与HOMA-IR、HOMA -β的相关性.结果 T2DM组患者血糖、血脂、HOMA-IR高于正常对照组(P＜0.05),而HOMA-β、25(OH)D3低于正常对照组(P＜0.05),Pearson相关分析显示T2DM组患者血清25 (OH) D3与HOMA-IR呈负相关(r=-0.55,P均＜0.05),与HOMA-β呈正相关(r =0.63,P＜0.05).结论 新诊断T2DM患者血清25(OH)D3的缺乏与胰岛素抵抗和胰岛β细胞分泌功能下降有关.%Objective To investigate the changes of serum 25-hydroxy vitamin D3in newly diagnosed type 2 diabetes mellitus,and analysis the significance of serum 25-hydroxy vitamin D3 in newly diagnosed type 2 diabetes mellitus.Methods Totally 118 newly diagnosed type 2 diabetes mellitus patients were compared with 60 healthy individuals in clinical characteristics including blood glucose,lipid profiles,insulin resistance
新诊断2型糖尿病患者血清25-羟维生素D3的临床意义
