Interventions to improve chronic cyclosporine A nephrotoxicity through inhibiting renal ce

Interventions to improve chronic cyclosporine A nephrotoxicity through inhibiting renal cell

apoptosis: a systematic review

XIAO Zheng;LI Cheng-wen;SHAN Juan;LUO Lei;FENG Li;LU Jun;LI Sheng-fu

【期刊名称】《中华医学杂志（英文版）》 【年(卷),期】2013(126)019

【摘要】Objective To reveal interventions for chronic cyclosporine A nephrotoxicity (CCN) and provide new targets for further studies,we analyzed all relevant studies about interventions in renal cell apoptosis.Data sources We collected all relevant studies about interventions for cyclosporine A (CsA)-induced renal cell apoptosis in Medline (1966 to July 2010),Embase (1980 to July 2010) and ISI (1986 to July 2010),evaluated their quality,extracted data following PICOS principles and synthesized the data.Study selection We included all relevant studies about interventions in CsA-induced renal cell apoptosis no limitation of research design and language) and excluded the duplicated articles,meeting abstracts and reviews without specific data.Results There were three kinds of intervention,include anti-oxidant (sulfated

polysaccharides,tea

(recombinant

polyphenols,apigenin,curcumin,spirulina,etc),biologics

human erythropoietin (rhEPO),a murine pan-specific transforming growth

factor

(TGF)-beta-neutralizing

monoclonal