Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPL

Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC

and tandem MS techniques

Mo Chen;Yuan Zhang;Xiao-Ting Que;Ya Ding;Lin Yang;Ai-Dong Wen;Tai-Jun Hang

【期刊名称】《药物分析学报（英文）》 【年(卷),期】2013(000)006

【摘要】Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokinetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chinese volunteers. The established LC/MS/MS method for plasma DIP determination had a linear range of 0.02-10 mg/mL, and the HPLC method for plasma PABA determination had a linear range of 0.05-40 mg/mL. Linear pharmacokinetic characteristics were found with single oral doses of 0.5, 1.0 and 2.0 g. No obvious accumulation effects were observed for DIP and PABA. 【总页数】7页(387-393) 【关键词】

【作者】Mo Chen;Yuan Zhang;Xiao-Ting Que;Ya Ding;Lin Yang;Ai-Dong Wen;Tai-Jun Hang

【作者单位】Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China;Department of

Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009,

China;Department

of

Pharmaceutical

Analysis,

China

Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmacy, Xijing Hospital, Xi'an 710032, China;Department of Pharmacy, Xijing Hospital, Xi'an 710032, China;Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China 【正文语种】英文 【中图分类】 【相关文献】

1.Simultaneous Determination of Pinoresinol Di-gluco-pyranoside and Pinoresinol Glucoside in Rat Plasma by HPLC-tandem MS/MS for Pharmacokinetic Study [J], Er-wei Liu[1]; Yan-ping Lin[2]; Lei Wang[3]; Yan Huo[4]; Ying-yue Zhang[4]; Jia-ding Guo[4]; Li-feng Han[3]; Yan-xu Chang[1]; Xiu-mei Gao[5]

2.Simultaneous Determination of Pinoresinol Di-gluco-pyranoside and Pinoresinol Glucoside in Rat Plasma by HPLC-tandem MS/MS for Pharmacokinetic Study [J], Er-wei Liu; Yan-ping Lin; Lei Wang; Yan Huo; Ying-yue Zhang; Jia-ding Guo; Li-feng Han; Yan-xu Chang; Xiu-mei Gao

3.Determination of fenticonazole in human plasma by HPLC-MS/MS and

its application to pharmacokinetic studies [J], Weixing Mao; Yiya Wang; Wenhui Hu; Feifei Jiao; Hongwei Fan; Li Ding

4.Simultaneous quantitation of folic acid and 5-methyltetrahydrofolic acid in human plasma by HPLC-MS/MS and its application to a pharmacokinetic study☆ [J], Xiao-Hong Zheng; Li-Yuan Jiang; Lan-Ting Zhao; Quan-Ying Zhang; Li Ding

5.Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ, a novel anticancer makaluvamine analog, and application in a pharmacokinetic study in rats [J], YU Jun-Xian; Sukesh Voruganti; LI Dan-Dan; Jiang-Jiang Qin; Subhasree Nag; Su Xu; Sadanandan E.Velu

以上内容为文献基本信息，获取文献全文请下载