Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPL
Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC
and tandem MS techniques
Mo Chen;Yuan Zhang;Xiao-Ting Que;Ya Ding;Lin Yang;Ai-Dong Wen;Tai-Jun Hang
【期刊名称】《药物分析学报(英文)》 【年(卷),期】2013(000)006
【摘要】Inosiplex is a compound formulation composed of inosine and p-acetaminobenzoic acid (PABA) salt of N,N-dimethylamino-2-propanol (DIP). This study was to investigate the clinical plasma pharmacokinetic properties of DIP and PABA after single and multiple oral doses of inosiplex tablets in healthy Chinese volunteers. The established LC/MS/MS method for plasma DIP determination had a linear range of 0.02-10 mg/mL, and the HPLC method for plasma PABA determination had a linear range of 0.05-40 mg/mL. Linear pharmacokinetic characteristics were found with single oral doses of 0.5, 1.0 and 2.0 g. No obvious accumulation effects were observed for DIP and PABA. 【总页数】7页(387-393) 【关键词】
【作者】Mo Chen;Yuan Zhang;Xiao-Ting Que;Ya Ding;Lin Yang;Ai-Dong Wen;Tai-Jun Hang
【作者单位】Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China;Department of
Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009,
China;Department
of
Pharmaceutical
Analysis,
China
Pharmaceutical University, Nanjing 210009, China;Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China;Department of Pharmacy, Xijing Hospital, Xi'an 710032, China;Department of Pharmacy, Xijing Hospital, Xi'an 710032, China;Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China 【正文语种】英文 【中图分类】 【相关文献】
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Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPL
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