非ACTH依赖性双侧肾上腺大结节增生患者的临床特点分
析
张倩;巴建明;母义明;陆菊明;潘长玉;窦京涛;谷伟军;杜锦;王先令;杨国庆;郭清华;杨丽娟;吕朝晖
【期刊名称】《中华内分泌代谢杂志》 【年(卷),期】2011(027)011
【摘要】Objective To study the clinical features of patients with ACTH-independent
bilateral
macronodular
adrenal
hyperplasia(AIMAH).Methods Eighteen cases with AIMAH diagnosed in Chinese PLA General Hospital from 1998 to 2010 were analyzed retrospectively.Results ( 1 ) AIMAH was equally distributed between genders,mean age at diagnosis was ( 51.4 ± 10.7 ) years,and average course was ( 9.9:t:2.7 ) years.( 2 )Most patients visited hospital because of adrenal incidentaloma; hypertension and impaired glucose tolerance/diabetes
mellitius
were
the
most
common
clinical
presentations; typical signs of Cushing′s syndrome (CS) such as moon face and central obesity were less frequent.( 3 ) All cases′ laboratory findings met the diagnostic criteria of ACTH-independent CS,some cases with the features of subclinical CS.24 h dynamic plasma ACTH and cortisol monitoring had the advantage of revealing the features of subclinical CS for some AIMAH cases; there was remarkable elevation of plasma cortisol after exogenous ACTH stimulation in AIMAH patients.(4) Bilateral adrenal macronodular changes could be visualized on CT
非ACTH依赖性双侧肾上腺大结节增生患者的临床特点分析
