粪便初次级胆汁酸检测在诊治婴儿胆汁淤积性肝病中的意
义
李檬;刘四香;王明英;胡红卫;尹建雯;刘梅;丁臻博;黄永坤
【期刊名称】《中国实用儿科杂志》 【年(卷),期】2019(034)004
【摘要】Objective To detect the level of fecal primary and secondary bile acids in infants with infantile cholestatic hepatopathy (ICH) and analyze its clinical value. Methods Thirty infants with ICH were enrolled in this study, who were diagnosed with infantile cholestatic hepatopathy. Thirty infants with good health condition were enrolled as the healthy control group. The fecal samples were collected respectively in the preparatory treatment phase and treatment phase from infants with ICH and from the healthy infants. Bile acids were extracted from infants' feces and were quantitatively analyzed by liquid chromatography-mass spectroscopy. Results Among the fecal primary bile acids, the level of cholic acid, chenodeoxycholic and glycochenodeoxycholic acid both in the ICH preparatory treatment group and ICH treatment group was significantly lower than that in the healthy control group (P＜0.016).The level of fecal cholic acid and chenodeoxycholic acid of ICH treatment group was higher than in the ICH preparatory treatment group (P＜0.016).Among the fecal secondary bile acids, the level of lithocholic acid both in the ICH preparatory treatment group and ICH treatment group
粪便初次级胆汁酸检测在诊治婴儿胆汁淤积性肝病中的意义
