C肽对2型糖尿病肾病的保护作用及其机制的研究
张东铭;田晨光;李青菊;钱镭;付艳芹;辛雅萍;张苏河
【期刊名称】《中国实用医刊》 【年(卷),期】2011(038)018
【摘要】目的 探讨C肽对2型糖尿病肾病的保护作用及其机制.方法 将66例2型糖尿病患者分为单纯胰岛素组和磺脲类降糖药组,记录年龄、性别、体质量指数(BMI)、病程等一般项目并测定空腹血糖、血浆C肽浓度、糖化血红蛋白.用酶比色法测定红细胞膜ATP酶及血浆一氧化氮水平并进行比较,分析其与C肽等指标的相关性；分析C肽水平与2型糖尿病肾病分期的关系.结果 ①2型糖尿病单纯胰岛素组红细胞膜ATP酶活性和血浆一氧化氮水平较磺脲类降糖药组为低(P＜0.05)；②2型糖尿病患者红细胞膜ATP酶活性与血浆C肽水平和胰岛素水平呈正相关,红细胞膜ATP酶活性与病程和年龄呈负相关；③2型糖尿病肾病的分期随血浆C肽浓度降低而逐渐升高.结论 C肽通过改善2型糖尿病肾病患者红细胞膜ATP酶活性减轻肾脏损害.%Objective To study the protective effect of C - peptide on diabetic nephropathy and its mechanism.Methods Sixty - six cases of type 2 diabetes were divided into two groups( insulin therapy group and insulin secretagogue therapy group).Age,sex,BMI,course of disease were recorded and fasting blood glucose,plasma C -peptide levels and glycated hemoglobin were detected. Erythrocyte membrane ATPase activity and the level of plasma nitric oxide were detected by enzyme colorimetrie method.The relationships between C - peptide levels and the stages of diabetic
nephropathy in type 2 diabetes were analyzed.Results ①Erythrocyte membrane ATPase activity and plasma nitric oxide levels were lower in insulin therapy group than those in insulin secretagogue therapy group (P ＜ 0.05 ).②In type 2 diabetes,erythrocyte membrane ATPase activity was positively correlated with plasma C -peptide and insulin levels,while erythrocyte membrane ATPase activity was negatively correlated with course of disease and age.③The phases of diabetic nephropathy gradually increased accompany with the decrease of plasma C - peptide level.Conclusions C - peptide could reduce kidney damage in type 2 diabetic nephropathy by elevating erythrocyte membrane ATPase activity.
【总页数】3页(14-15,18)
【关键词】C肽;胰岛素;2型糖尿病;糖尿病肾病
【作者】张东铭;田晨光;李青菊;钱镭;付艳芹;辛雅萍;张苏河
【作者单位】450014 郑州大学第二附属医院内分泌科;450014 郑州大学第二附属医院内分泌科;450014 郑州大学第二附属医院内分泌科;上海市第一人民医院;450014 郑州大学第二附属医院内分泌科;450014 郑州大学第二附属医院内分泌科;450014 郑州大学第二附属医院内分泌科 【正文语种】中文 【中图分类】 【文献来源】
https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-
journal-practical-medicine_thesis/0201255390938.html 【相关文献】
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C肽对2型糖尿病肾病的保护作用及其机制的研究
