脂氧素受体激动剂BML-111对左向右分流型肺动脉高压
大鼠作用的影响
龚兴瑞;陈永梅;向勇;许先成;王贤裕;秦成名
【期刊名称】《海南医学》 【年(卷),期】2013(024)002
【摘要】Objective To observe the effect of BML-111 on pulmonary arterial pressure and inflammation of rats with pulmonary hypertension induced by left-to-right shunt. Methods Thirty SD rats were randomly divided into three groups: C group, PH group and B group. Both PH group and B group applied left common carotid artery-external jugular vein shunt and left femoral artery-vein shunt. Six weeks later, rats in B group received intraperitoneal injection of BML-111 1 mg·kg-1·d-1, while those in PH group received saline injection for four weeks. The rats in C group were treated by intraperitoneal injection of saline. The MPAP, RVSP, RV/(LV+S), the ratio of media thickness of pulmonary arterioles, distal arteriole muscularization and the count of neointimal proliferation, and the level of IL-6, TNF-α, MCP-1 of pulmonary tissue were compared between the three groups. Results Compared with C group, the PH group and B group has significantly higher levels of MPAP, RVSP, RV/(LV+S), the ratio of media thickness of pulmonary arterioles, distal arteriole muscularization and the count of neointimal proliferation, and significantly higher levels of IL-6, TNF-a, MCP-1 in pulmonary tissue
脂氧素受体激动剂BML-111对左向右分流型肺动脉高压大鼠作用的影响
