CD40-CD40L在儿童持续性免疫性血小板减少症发病机制中的作用研究

CD40-CD40L在儿童持续性免疫性血小板减少症发病机制

中的作用研究

邓彩艳;马占敏;胡玉莲

【期刊名称】《中国医药科学》 【年(卷),期】2014(000)007

【摘要】Objective To investigate the expression of CD40 and CD40L in peripheral blood mononuclear cells of patients with childhood Persistent immune thrombocytopenia(Persistent ITP), and to explore their possible roles in the pathogenesis of the disease. Methods The positivity rates of CD40 and CD40L in peripheral blood mononuclear cells were measured by flow cytometry in 20 Persistent ITP patients (prior treatment and post treatment) and 20 normal controls. Platelet-associated antibody(PAIgG) were detected by enzyme linked immunosorbent assay (ELISA) technique. Results Compared with controls, the expression of CD40 and CD40L were higher in both prior treatment group and post treatment group(P<0.01,P<0.05), Compared with post treatment group, the expression of CD40 in prior treatment group were higher(P<0.05=. The expression of CD40 and CD40L had positive correlation with PAIgG (r=0.713, 0.746;P<0.05). Conclusion CD40 and CD40L pathway may play important roles in the pathogenesis of Persistent ITP, and it is possible to be a good therapeutic target if we can obstruct this way.%目的：通过检测CD40-CD40L在持续性免疫性血小